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RP 70676

CAS No. 136609-26-2

RP 70676 ( —— )

产品货号. M26422 CAS No. 136609-26-2

RP 70676 是一种有效的 ACAT 抑制剂(大鼠和兔 ACAT,IC50 分别为 25 和 44 nM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2341 有现货
10MG ¥3872 有现货
25MG ¥6391 有现货
50MG ¥8748 有现货
100MG ¥11988 有现货
500MG ¥24057 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    RP 70676
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    RP 70676 是一种有效的 ACAT 抑制剂(大鼠和兔 ACAT,IC50 分别为 25 和 44 nM)。
  • 产品描述
    RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).(In Vitro):RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.(In Vivo):In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.
  • 体外实验
    RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM.
  • 体内实验
    RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Human Endogenous Metabolite
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    136609-26-2
  • 分子量
    416.59
  • 分子式
    C25H28N4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 125 mg/mL (300.06 mM)
  • SMILES
    Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Ouzir M, Bouhaddou N, Khalki H, Lakhdar-Ghazal N. Physiological and pharmacological properties of 5-methoxytryptophol. Expert Rev Endocrinol Metab. 2013 Jul;8(4):355-364.
产品手册
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