
RP 70676
CAS No. 136609-26-2
RP 70676 ( —— )
产品货号. M26422 CAS No. 136609-26-2
RP 70676 是一种有效的 ACAT 抑制剂(大鼠和兔 ACAT,IC50 分别为 25 和 44 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2341 | 有现货 |
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10MG | ¥3872 | 有现货 |
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25MG | ¥6391 | 有现货 |
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50MG | ¥8748 | 有现货 |
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100MG | ¥11988 | 有现货 |
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500MG | ¥24057 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RP 70676
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述RP 70676 是一种有效的 ACAT 抑制剂(大鼠和兔 ACAT,IC50 分别为 25 和 44 nM)。
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产品描述RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).(In Vitro):RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.(In Vivo):In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.
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体外实验RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM.
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体内实验RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.
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同义词——
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通路Others
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靶点Other Targets
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受体Human Endogenous Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number136609-26-2
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分子量416.59
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分子式C25H28N4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (300.06 mM)
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SMILESCc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ouzir M, Bouhaddou N, Khalki H, Lakhdar-Ghazal N. Physiological and pharmacological properties of 5-methoxytryptophol. Expert Rev Endocrinol Metab. 2013 Jul;8(4):355-364.
产品手册




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